Meclofenamic acid ( Meclofenamate )

产品货号. M26293 CAS No. 644-62-2

甲氯芬那酸是一种非选择性间隙连接阻滞剂和选择性脂肪量和肥胖相关 (FTO) 酶抑制剂。甲氯芬那酸具有抗炎活性。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥5928	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Meclofenamic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

甲氯芬那酸是一种非选择性间隙连接阻滞剂和选择性脂肪量和肥胖相关 (FTO) 酶抑制剂。甲氯芬那酸具有抗炎活性。
产品描述

Meclofenamic acid is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.
体外实验

Meclofenamic acid (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner.Meclofenamic acid inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins.Meclofenamic acid inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins. Western Blot Analysis Cell Line:HeLa cells Concentration:0, 12.5, 25, 50, 100 μM Incubation Time:24 h Result:Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.
体内实验

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同义词

Meclofenamate
通路

Others
靶点

Other Targets
受体

Major prion protein
研究领域

——
适应症

——

化学信息

CAS Number

644-62-2
分子量

296.15
分子式

C14H11Cl2NO2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (337.67 mM)
SMILES

Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056.

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摩尔计算器

分子量计算器

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